DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanisms*
نویسنده
چکیده
The transforming growth factor-beta 1 (TGFβ1) promotes fibrosis, differentiating epithelial cells and quiescent fibroblasts into myofibroblasts and increasing expression of extracellular matrix. Recent investigations have shown that PPAR (peroxisome proliferator-activated receptor*) is a negative regulator of fibrotic events induced by TGFβ1. Dehydroepiandrosterone (DHEA) is an immunomodulatory hormone essential for PPAR functions, and is reduced in some processes characterized by fibrosis. Although scarring alopecia characteristically develops in the female biological period in which occurs decreased production of DHEA, there are no data in the literature relating its reduction to fibrogenic process of this condition. This article aims to review the fibrogenic activity of TGFβ1, its control by PPAR and its relation with DHEA in the frontal fibrosing alopecia.
منابع مشابه
Development of Frontal Fibrosing Alopecia with a History of Alopecia Areata
Frontal fibrosing alopecia (FFA), a scarring type of alopecia, developed in two patients with a history of alopecia areata (AA). Both patients had biopsies to confirm this interesting series of pathology. Etiology and pathogenesis of this AA-to-FFA sequence will be discussed.
متن کامل[Frontal fibrosing alopecia: A case report].
Frontal fibrosing alopecia (FFA) was first proposed by Kossard in 1994 with the term “postmenopausal frontal fibrosing alopecia”. FFA is an acquired scarring alopecia presenting as symmetrical recession of frontal and temporal hairlines as well as eyebrow loss. The exact pathophysiology of FFA has not been elucidated and the optimal treatment is still unknown. The majority of the cases are post...
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Frontal fibrosing alopecia (FFA) is a lymphocyte-mediated scarring alopecia thought to be a variant of lichen planopilaris (LPP). We present a 67-year-old woman with frontal fibrosing alopecia whose daughter was diagnosed to have lichen planopilaris. Both patients had identical human leukocyte antigen (HLA) D types, supporting a phenotypical relationship between the two clinical entities. Inter...
متن کاملFrontal fibrosing alopecia and lichen planus pigmentosus: diagnosis and therapeutic challenge*
Frontal fibrosing alopecia is a variant of lichen planopilaris with marginal progressive hair loss on the scalp, eyebrows and axillae. We report a case of frontal fibrosing alopecia and lichen planus pigmentosus in a postmenopausal woman, that started with alopecia on the eyebrows and then on the frontoparietal region, with periocular and cervical hyperpigmentation of difficult management. The ...
متن کاملPostmenopausal frontal fibrosing alopecia
Postmenopausal frontal fibrosing alopecia (PFFA) is a new clinical entity that can be regarded as a version of lichen plano-pilaris with fronto-temporal, and more rarely, eyebrow localization. Kossard et al. (1) was the first to describe the first six cases in elderly Australian female patients. Later on, a clinical and immune-histological evaluation of another 10 cases (2), as well as further ...
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